CBD has antimicrobial properties that help in its activity against seasonal allergies by helping to reduce the irritation caused at the throat and sinuses. The endocannabinoid system also has a large role to play in this with the two major cannabinoid receptors CB1 and CB2 found majorly in the nervous system and immune system respectively being implicated in causing inflammation. This inflammation at the sinuses accounts for a large part of the reaction of the body to allergens and the interaction of CBD with these receptors can help to reduce inflammation by stabilizing the endocannabinoid system and the neurotransmitters that mediate it.