Caryophyllene has a unique molecular structure. Specifically, it’s because it has a rare cyclobutene ring that isn’t found in other cannabis terpenes. When you consume cannabis high in caryophyllene, internally it easily binds to the CB2 receptors unlike THC which binds to the CB1 receptors. This is why THC causes a psychoactive effect but caryophyllene doesn’t produce a high. However, it will still enable you to feel its therapeutic benefits especially reducing inflammation.