It’s every cannabis lover’s nightmare. Cannabis Hyperemesis Syndrome (CHS) is a very rare syndrome that affects long-term, heavy users of THC-rich cannabis. Its symptoms include nausea, vomiting, abdominal pain, and loss of appetite. In extreme cases, CHS-sufferers can experience severe weight loss and dehydration, which can lead to muscle spasms, seizures, and kidney failure if not treated. In rare cases, it can even lead to death.