The lipid signaling system has two G-protein coupled receptors called CB1 and CB2 receptors. It also has endogenous polyunsaturated fatty acid ligands, the endocannabinoid system, and enzymes involved in its biosynthesis and degradation. The system is well preserved throughout the ages. This suggests then that the endocannabinoid system plays a huge role in the preservation of energy through biological processes. In the lipid signaling system, the endocannabinoid system is over-activated and proper research could lead to a promising treatment for obesity.