![](https://cannabis.net/drive/1000/3743_aRtg_cbdglucose.jpg?width=200&height=200)
Remarkably, at three months of age, only male offspring exposed to CBD showed signs of glucose intolerance. The authors speculate that estrogen-mediated mechanisms may have prevented female rats from acquiring glucose intolerance, given estrogen’s established protective effect against metabolic dysfunction. To validate this theory, more research is necessary.