The authors assumed that people who admitted they consumed cannabis regularly would report more pain sensitivity, though they did not find any difference. “There is a different effect from opioid users; sustained use of opioids can make people more reactive to pain. We wanted to determine if there was a similar trend for people who use cannabis frequently,” she says. “Cannabis and opioids share some of the same pain-relief pathways and have both been associate with increases in pain sensitivity following acute use.”