he endocannabinoid system is linked to the possibility of cannabis being beneficial to bone health. This system which is made up of receptors, enzymes and signaling molecules, plays a regulatory role in the body. Part of the body functions which this system regulates, is bone remodeling. The receptors in the endocannabinoid system that are linked to bone health are, cannabinoid receptor 1 (CB1), cannabinoid receptor 2 (CB2), as well as transient receptor potential vanilloid 1 (TRPV1). While TRPV1 and CB1 aid the breaking down of old tissue, CB2 assists in osteoclast activity of laying down new bones. As a result of the effectiveness of these cannabinoid receptors in the body, THC and CBD are being explored as tools for promoting good bone health. At this point THC and CBD are being put experimented in cases like rheumatoid arthritis, osteoporosis and fractures.
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