Following their earlier discovery as the major cannabinoid receptors present in the body, many studies have gone into CB1 and CB2 receptors but the presence of a third cannabinoid receptor in GPR55 makes the endocannabinoid system broader with a need to look deeper to its relationship with the cannabinoids and the effects that their interactions. GPR55 is a G-protein coupled receptor discovered in 1999 and has a 13% and 14.4% similarity with CB1 and CB2 cannabinoid receptors respectively. GPR55 receptors are found in the brain and peripheral nerves and have been implicated in numerous therapeutic actions.