The pineal gland has a functional endocannabinoid system. Both CB1 and CB2 receptors, as well as the endogenous ligands that bind them, anandamide, and 2-AG, are present. The activity of the CB1 receptors varies according to a daily cycle. The lowest activity occurs at the end of the daylight period. The enzyme responsible for synthesizing new endocannabinoid molecules, NAPE-PLD, gets reduced during the middle of the dark period.
The years-long push to lock foreign visitors out of the city’s coffeeshops just died in…
When most people think about major hip-hop festivals, Montana rarely enters the conversation. For decades,…
From a black currant sour to an espresso martini riff, here are five THC cocktails…
In the music video for “Ram Pam Pam,” Venezuelan artist Micro TDH put older women…
The new cannabis beverage boom isn’t really about replacing booze. It’s about replacing everything people…
Amber Senter co-founded Supernova Women, the organization that helped shape America’s first cannabis social equity…