A study out of the Imperial College London’s Centre for Psychedelic Research found that psilocybin mushrooms were effective in helping to open up the brains of participants suffering from depression, even weeks after consumption. Almost 60 subjects joined in the trials, which yielded positive results. For the methodology, researchers assessed fMRI scans of individuals from the trials: in one study all of them were given psilocybin while for another, they used a randomized control trial for general depression that assessed the efficacy of psilocybin against escitalopram, a common SSRI medication used for treating depression.