The kidneys play an important role in both cardiovascular function and the excretion of waste in the body. Therefore, when the kidneys do not function properly, other physiological processes in the body are indirectly affected. This includes blood pressure control, heart rate, sodium excretion, and water/salt balance. The good thing is that the kidneys have one of the highest expressions of CB1 and CB2 receptors. Both endogenous and cannabis cannabinoids can alter the function of the kidneys.