According to Cermak, taking a prolonged break from weed would “up regulate” your receptors meaning, that you’d be able to have greater quantities of THC biologically available to you. You’d have more receptors “open for business”. Therefore, if you’re reaching a point where it gets more difficult to get high or you’re simply “meh” about most things in life – taking a short break to purge yourself from access cannabinoids and to up regulate your receptors would be a good thing.