The endocannabinoid system portrays sex differences. The sex hormones testosterone in men and estrogen and progesterone in women have a different influence on the endocannabinoid system, especially the network of brain cells that use the same system of communication than cannabinoids. The estrogen hormone is the one that affects women the most in the consumption of cannabis. One of the functions of estrogen is to regulate a fatty acid amide hydrolase (FAAH), which diminishes the effect of anandamide
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